How NMN Can Lower Your Blood Pressure and Protect Your Heart
If you have high blood pressure, or hypertension, you know how dangerous it can be for your health. Hypertension increases your risk of heart attack, stroke, kidney failure, and other serious complications. It can also damage your blood vessels, making them stiff and narrow, and impairing your blood flow.
But what if there was a natural way to lower your blood pressure and improve your blood vessel health, without any side effects or drugs? What if there was a supplement that could boost your body’s own ability to regulate your blood pressure and protect your heart?
Sounds too good to be true, right?
Well, that’s what some scientists are claiming about NMN, a molecule that has been shown to have remarkable effects on aging and health in animal studies. NMN stands for nicotinamide mononucleotide, and it’s a precursor to NAD+, a coenzyme that is essential for cellular energy and function.
NAD+ is involved in many vital processes in your body, such as metabolism, DNA repair, gene expression, and cellular stress responses. It’s also crucial for the health and function of your blood vessels, as it regulates the production of nitric oxide, a molecule that relaxes and dilates your blood vessels, and lowers your blood pressure.
However, as you age, your levels of NMN and NAD+ decline, which can lead to various health issues, including hypertension, cardiovascular disease, and metabolic syndrome. This is why some researchers believe that supplementing with NMN can restore your NAD+ levels and reverse some of the effects of aging on your blood vessels and heart.
But does NMN really work for lowering blood pressure and improving blood vessel health in humans? And if so, how much should you take, and what are the potential side effects? In this blog post, we’ll explore the latest research on NMN and hypertension, and answer some of the most common questions about this promising supplement.
What does the research say about NMN and hypertension?
Several studies have shown that NMN can lower blood pressure and improve blood vessel health in animal models of hypertension. For example, a study by Yoshino and colleagues from Washington University School of Medicine found that injecting 500 mg/kg/day of NMN for four weeks reduced systolic blood pressure (the pressure when your heart beats) by 18 mmHg in mice with angiotensin II-induced hypertension, a common model of human hypertension¹. NMN also improved the function and structure of the aorta, the main artery that carries blood from the heart to the rest of the body.
Another study by de Picciotto and colleagues from the University of Cambridge found that feeding 400 mg/kg/day of NMN for eight weeks reduced systolic blood pressure by 15 mmHg in mice with salt-sensitive hypertension, another model of human hypertension². NMN also increased the levels of nitric oxide and reduced the levels of oxidative stress and inflammation in the blood vessels.
A recent study by Liu and colleagues from the Chinese Academy of Medical Sciences compared the effects of NMN and NR, another NAD+ precursor, on blood pressure and blood vessel health in rats with hypertension induced by a high-fat diet³. They found that both NMN and NR significantly reduced systolic blood pressure by 20-30 mmHg, and improved the function and structure of the blood vessels. The researchers also found that NMN and NR increased the expression of genes that promote blood vessel health, such as SIRT1, eNOS, and FOXO3a.
These studies provide the first evidence that NMN can lower blood pressure and improve blood vessel health in various models of hypertension. However, more research is needed to confirm the safety and efficacy of NMN for human hypertension, and to determine the optimal dose and duration of NMN supplementation.
What are the benefits of NMN for blood pressure and blood vessel health?
Based on the animal studies, NMN may have several benefits for blood pressure and blood vessel health, such as:
– Lowering systolic blood pressure, which is a major risk factor for cardiovascular disease and stroke.
– Improving the function and structure of the blood vessels, which can enhance blood flow and oxygen delivery to the organs and tissues.
– Increasing the production of nitric oxide, which can relax and dilate the blood vessels, and lower blood pressure.
– Reducing the levels of oxidative stress and inflammation, which can damage the blood vessels and cause atherosclerosis, or plaque buildup in the arteries.
– Activating genes that promote blood vessel health, such as SIRT1, eNOS, and FOXO3a, which can regulate cellular stress responses, DNA repair, and lifespan.
By improving blood pressure and blood vessel health, NMN may also have other benefits for cardiovascular health, such as:
– Preventing or delaying the development of hypertension, which can lead to various complications, such as heart failure, kidney failure, and dementia.
– Protecting against heart damage and dysfunction, which can result from hypertension, ischemia, or lack of blood supply to the heart, or cardiotoxicity, or toxicity caused by drugs or chemicals.
– Enhancing cardiac performance and endurance, which can improve physical activity and quality of life.
How much NMN should you take for blood pressure and blood vessel health?
The optimal dose of NMN for blood pressure and blood vessel health is not yet established, but most studies in animals used doses ranging from 100 to 500 mg/kg/day. For humans, this would translate to about 8 to 40 mg/kg/day, or 560 to 2800 mg/day for a 70 kg person. However, these doses are based on animal studies, and may not be applicable to humans. You may want to start with a lower dose and gradually increase it, depending on your response and tolerance.
You should also consult your doctor before taking NMN, especially if you have any existing medical conditions, or if you’re taking any medications or supplements. NMN is generally considered safe and well-tolerated, but it may interact with some drugs or affect your blood sugar levels, blood pressure, or liver function.
What are the potential side effects of NMN for blood pressure and blood vessel health?
NMN is generally considered safe and well-tolerated, but some people may experience some mild and transient side effects, such as:
– Nausea, diarrhea, or stomach discomfort, which may be due to the high dose or the rapid absorption of NMN.
– Headache, fatigue, or dizziness, which may be due to the changes in blood pressure or blood sugar levels.
– Allergic reactions, such as rash, itching, or swelling, which may be due to the individual sensitivity or the quality of the NMN product.
These side effects are usually mild and subside within a few hours or days. However, if you experience any severe or persistent side effects, you should stop taking NMN and consult your doctor.
How to choose a high-quality NMN product for blood pressure and blood vessel health?
If you’re interested in taking NMN for blood pressure and blood vessel health, you should choose a high-quality NMN product that is pure, tested, and verified by a third-party lab. There are many NMN products on the market, but not all of them are reliable or effective. You should look for a product that has a certificate of analysis (COA) that shows the amount and purity of NMN, and that is free of contaminants, such as heavy metals, pesticides, or microbes.
You should also choose a product that has a good delivery system, such as capsules, tablets, or sublingual lozenges, that can ensure the stability and bioavailability of NMN. Some NMN products may have additives, such as resveratrol, pterostilbene, or quercetin, that can enhance the effects of NMN, but you should check the ingredients and dosage carefully, and consult your doctor before taking them.
Conclusion
NMN is a promising supplement that can boost NAD+ levels and blood vessel health, and potentially lower blood pressure and prevent or delay hypertension. NMN has been shown to have beneficial effects on blood pressure and blood vessel health in animal models of hypertension, but more research is needed to confirm its effects in humans. If you want to try NMN for blood pressure and blood vessel health, you should consult your doctor, choose a high-quality product, follow the dosage instructions, monitor your blood pressure and other health parameters, and adopt a healthy lifestyle. NMN may help you lower your blood pressure and protect your heart, but it’s not a substitute for proper medical care and attention.
Source: 03/02/2024
(1) NMN (Nicotinamide Mononucleotide): Benefits, Side Effects … – Healthline. https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage.
(2) Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure … – nad. https://www.nad.com/news/harvard-study-nmn-cuts-weight-cholesterol-and-blood-pressure-in-overweight-adults.
(3) NMN Lowers Blood Pressure in Patients with Hypertension: Latest Human Trial. https://www.nmn.com/news/nmn-lowers-blood-pressure-in-patients-with-hypertension-latest-human-trial.
(4) Promising NMN Study: Lower Hypertension & Boost Blood Vessel Health. https://eightify.app/summary/health-and-medicine/promising-nmn-study-lower-hypertension-boost-blood-vessel-health.
(5) NMN Reduces Weight, Cholesterol, and Blood Pressure in Overweight …. https://www.nmn.com/news/nmn-reduces-weight-cholesterol-and-blood-pressure-in-overweight-adults-harvard-medical-school-study.
NMN from partiQlar has the highest purity in the market – above 99%. The Purity of NMN is confirmed by the third-party laboratory. The NMN raw material is supplied by leading supplier Effepharm, which has a research and development team led by US experts from GlaxoSmithKline, a research-based pharmaceutical and healthcare company that has established itself as a world-class leader in both medicine and healthcare. Effefarm’s scientific quality standard-setting team is led by a former (USP) scientist who ensures that NMN strictly complies with USP quality standards. Our manufacturing facilities in the US are certified by NSF and UL for Good Manufacturing Practice (GMP) conformance.