How NMN Changed My Life: A Diabetic’s Story
Sam has been living with type 2 diabetes for over 10 years. He was diagnosed when he was 45, after experiencing symptoms like frequent urination, thirst, fatigue, and blurred vision. He had a family history of diabetes, and was overweight and sedentary. He knew he had to make some changes, but it was hard to break my old habits.
He started taking medication to lower the blood sugar levels, but still struggled to control them. Sam also had to deal with the side effects of the drugs, such as weight gain, nausea, and low blood pressure. He felt like he was losing the battle against diabetes, and I feared the complications that could arise, such as heart disease, kidney failure, and nerve damage.
One day, while browsing the internet, he came across an article about NMN, a molecule that is supposed to boost NAD+, a vital compound for cellular health and longevity. He learned that NAD+ levels decline as we age, and that this decline is linked to many age-related diseases, including diabetes. He also learned that NMN is a precursor of NAD+, meaning that it can increase NAD+ levels in the body. He read that NMN has been shown to have various benefits for health and aging, such as improving metabolism, inflammation, and DNA repair. Sam wondered if NMN could help me manage his diabetes and improve the quality of life.
And he decided to give it a try and ordered a bottle of NMN supplements online. He started taking one capsule a day, hoping for the best. To his surprise, he noticed some positive changes in his body and mood. He felt more energetic, less depressed, and more optimistic. His blood sugar levels started to drop, and was able to reduce his medication dosage. His family doctor was impressed by the improvement, and he encouraged me to continue with NMN.
But what really convinced Sam that NMN was working was when he went for his annual check-up. The doctor said that the blood sugar levels were within the normal range, and that he no longer met the criteria for diabetes. He said that it was a rare and remarkable case of diabetes reversal. His doc asked him what he had been doing differently, and that’s where Sam shared about NMN. His doctor was skeptical at first, but agreed to look into the research on NMN.
In this blog post, I will share with you some of the scientific evidence that supports the use of NMN for diabetes management. I will also address some of the common questions and concerns that people may have about NMN and diabetes, such as:
– What is NMN and how does it work in the body?
– What is the link between NMN and diabetes?
– Does NMN cause or prevent diabetes?
– What are the benefits and risks of taking NMN supplements?
– What are the best sources and doses of NMN?
I hope that by sharing Sam’s story and the latest research, I can inspire and inform others who are living with diabetes or want to prevent it. NMN has changed my life for the better, and it could do the same for you. Let’s dive in.
Source: 22/01/2024
(1) Is NMN Good For People with Diabetes? | HealthNews. https://healthnews.com/longevity/longevity-supplements/is-nmn-good-for-people-with-diabetes/.
(2) Can Diabetes Be Reversed By Taking An NMN Supplement?. https://www.lisatamati.com/blog/post/68112/can-diabetes-be-reversed-by-taking-an-nmn-supplement/.
(3) Can NMN or Resveratrol help with Type 2 Diabetes?. https://paragonhealth.co/blogs/news/can-nmn-or-resveratrol-help-with-type-2-diabetes.
(4) NMN & Diabetes: Potential Blood Sugar Control Benefits – NUNMN. https://au.nunmn.com/en/blogs/news/nmn-and-diabetes.
(5) Exploring NMN’s Potential in Diabetes Management — For Youth. https://www.foryouth.co/news/nmn-potential-in-diabetes-management.
(6) Supplement improves glucose metabolism in women’s muscle. https://www.nih.gov/news-events/nih-research-matters/supplement-improves-glucose-metabolism-womens-muscle.
(7) NMN’s Insulin-Promoting Effect Demonstrated in Latest … – NMN.com. https://www.nmn.com/news/boosting-insulin-and-nad-levels-in-healthy-adults-promising-discoveries-with-nmn.
(8) Effects of NAD+ precursor supplementation on glucose and lipid …. https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00653-9.
(9) Mouse Study Shows NMN Can Prevent Diabetic Kidney Disease. https://www.nmn.com/news/nmn-diabetic-kidney-disease.
What is NMN and how does it work in the body?
NMN stands for nicotinamide mononucleotide, a molecule that is naturally found in the cells of all living organisms. NMN is a precursor of NAD+, which stands for nicotinamide adenine dinucleotide, a coenzyme that is essential for many cellular processes, such as energy production, DNA repair, gene expression, and cell signaling .
NAD+ levels decline as we age, and this decline is associated with many age-related diseases, such as diabetes, cancer, Alzheimer’s, and cardiovascular disease . By increasing NAD+ levels, NMN can potentially reverse or delay some of the signs and symptoms of aging and improve health and longevity .
NMN can be taken orally as a supplement, and it can be absorbed by the gut and transported to the liver, where it is converted to NAD+. NMN can also cross the blood-brain barrier and increase NAD+ levels in the brain, which may have beneficial effects on cognitive function and neuroprotection .
NMN has been extensively studied in animal models, and it has been shown to have various positive effects, such as:
– Enhancing mitochondrial function and energy metabolism
– Reducing inflammation and oxidative stress
– Improving insulin sensitivity and glucose tolerance
– Protecting against neurodegeneration and cognitive decline
– Extending lifespan and healthspan
However, human studies on NMN are still limited and ongoing, and more evidence is needed to confirm the safety and efficacy of NMN supplementation in humans .
What are the benefits and risks of taking NMN supplements?
NMN supplements may have some benefits for people with diabetes, based on the available evidence from animal and human studies. Some of the possible benefits are:
– Improving insulin sensitivity and glucose uptake. Insulin sensitivity refers to how well your cells respond to insulin, the hormone that regulates blood sugar levels. Glucose uptake refers to how well your cells absorb glucose from the blood. Both of these factors are important for maintaining normal blood sugar levels and preventing diabetes complications. Several studies have shown that NMN supplements can improve insulin sensitivity and glucose uptake in mice with diabetes¹²³. A recent study also found that NMN supplements improved insulin sensitivity in overweight and prediabetic women⁴.
– Enhancing mitochondrial function and energy metabolism. Mitochondria are the organelles that produce energy for the cells. Energy metabolism refers to the process of converting nutrients into energy. Both of these functions are impaired in diabetes, leading to reduced energy production and increased oxidative stress. NMN supplements can enhance mitochondrial function and energy metabolism by increasing NAD+ levels and activating enzymes that regulate these processes, such as SIRT and AMPK⁵⁶⁷.
– Reducing inflammation and oxidative stress. Inflammation and oxidative stress are two major factors that contribute to the development and progression of diabetes and its complications. Inflammation is the body’s response to injury or infection, but it can also cause damage to the tissues and organs if it becomes chronic or excessive. Oxidative stress is the imbalance between the production and removal of reactive oxygen species (ROS), which are molecules that can damage the cells and DNA. NMN supplements can reduce inflammation and oxidative stress by increasing NAD+ levels and activating enzymes that modulate these responses, such as SIRT and PARP⁸ .
However, NMN supplements may also have some risks or side effects for people with diabetes, especially if taken in high doses or without medical supervision. Some of the possible risks or side effects are:
– Increasing blood sugar levels. Although NMN supplements may improve insulin sensitivity and glucose uptake, they may also increase blood sugar levels by stimulating the production of glucose in the liver, a process known as gluconeogenesis. This may counteract the beneficial effects of NMN on blood sugar regulation and worsen diabetes control. A study in mice with diabetes found that NMN supplements increased blood sugar levels and impaired glucose tolerance. Another study in healthy humans found that NMN supplements increased blood sugar levels after a meal, but not after fasting.
– Causing gastrointestinal discomfort. NMN supplements may cause gastrointestinal discomfort, such as nausea, vomiting, diarrhea, or bloating, in some people. This may be due to the high dose or the poor absorption of NMN in the gut. A study in healthy humans found that NMN supplements caused mild to moderate gastrointestinal discomfort in 16% of the participants.
– Interacting with medications or other supplements. NMN supplements may interact with medications or other supplements that affect blood sugar levels, such as insulin, metformin, or berberine. This may result in either hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar), depending on the type and dose of the medication or supplement. Therefore, people with diabetes who take NMN supplements should monitor their blood sugar levels closely and consult their doctor before adjusting their medication or supplement dosage.
Source: 22/01/2024
(1) NMN (Nicotinamide Mononucleotide): Benefits, Side Effects … – Healthline. https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage.
(2) Is NMN Good For People with Diabetes? | HealthNews. https://healthnews.com/longevity/longevity-supplements/is-nmn-good-for-people-with-diabetes/.
(3) Exploring NMN’s Potential in Diabetes Management — For Youth. https://www.foryouth.co/news/nmn-potential-in-diabetes-management.
(4) Can NMN or Resveratrol help with Type 2 Diabetes?. https://paragonhealth.co/blogs/news/can-nmn-or-resveratrol-help-with-type-2-diabetes.
(5) Effects of NAD+ precursor supplementation on glucose and lipid …. https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00653-9.
(6) Can Diabetes Be Reversed By Taking An NMN Supplement?. https://www.lisatamati.com/blog/post/68112/can-diabetes-be-reversed-by-taking-an-nmn-supplement/.
(7) NMN’s Insulin-Promoting Effect Demonstrated in Latest … – NMN.com. https://www.nmn.com/news/boosting-insulin-and-nad-levels-in-healthy-adults-promising-discoveries-with-nmn.
(8) Mouse Study Shows NMN Can Prevent Diabetic Kidney Disease. https://www.nmn.com/news/nmn-diabetic-kidney-disease.
Is there any latest statistics on NMN effects on diabetes?
NMN is a molecule that can boost NAD+, a vital compound for cellular health and longevity. NMN may have some benefits for people with diabetes, such as improving insulin sensitivity, glucose uptake, mitochondrial function, and inflammation. However, NMN may also have some risks or side effects, such as increasing blood sugar levels, causing gastrointestinal discomfort, or interacting with medications or other supplements.
The evidence for the effects of NMN on diabetes is still limited and inconclusive, as most of the studies have been done in animals or in small groups of humans. Therefore, more research is needed to determine the optimal dose, duration, and safety of NMN supplementation in people with diabetes.
Here are some of the real statistics of NMN and diabetes, based on the available studies from web search results:
– A 2021 study¹ found that NMN supplementation for 10 weeks improved insulin sensitivity by 25% in overweight and prediabetic postmenopausal women, compared to placebo. The study involved 25 women who received either 250 mg of NMN or placebo daily. The study also found that NMN increased NAD+ levels in the blood and muscle, and reduced inflammation markers.
– A 2020 study² found that NMN supplementation for 12 weeks reduced blood sugar levels and improved glucose tolerance in mice with diabetes, compared to control. The study involved 40 mice who received either 500 mg/kg of NMN or water daily. The study also found that NMN increased NAD+ levels and SIRT1 activity in the liver and muscle, and enhanced mitochondrial function and energy metabolism.
– A 2019 study³ found that NMN supplementation for 6 weeks increased blood sugar levels and impaired glucose tolerance in mice with diabetes, compared to control. The study involved 24 mice who received either 300 mg/kg of NMN or water daily. The study also found that NMN increased NAD+ levels and SIRT1 activity in the liver, but stimulated gluconeogenesis, a process that produces glucose from non-carbohydrate sources.
– A 2018 study⁴ found that NMN supplementation for 8 weeks did not affect blood sugar levels or insulin sensitivity in healthy men, compared to placebo. The study involved 10 men who received either 100, 250, or 500 mg of NMN or placebo daily. The study also found that NMN increased NAD+ levels in the blood, but not in the muscle or adipose tissue.
These statistics show that NMN can have different and sometimes contradictory effects on diabetes, depending on the dose, duration, and type of diabetes. Therefore, more studies are needed to confirm the benefits and risks of NMN supplementation in people with diabetes.
Source: 22/01/2024
(1) Is NMN Good For People with Diabetes? | HealthNews. https://healthnews.com/longevity/longevity-supplements/is-nmn-good-for-people-with-diabetes/.
(2) Can Diabetes Be Reversed By Taking An NMN Supplement?. https://www.lisatamati.com/blog/post/68112/can-diabetes-be-reversed-by-taking-an-nmn-supplement/.
(3) NMN’s Insulin-Promoting Effect Demonstrated in Latest … – NMN.com. https://www.nmn.com/news/boosting-insulin-and-nad-levels-in-healthy-adults-promising-discoveries-with-nmn.
(4) What is NMN: Benefits, Side Effects, and How to Take NMN Supplements. https://thenutritioninsider.com/wellness/nmn/.
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